The psychiatric side-effects of rimonabant
Experimental affirmation has appropriate that drugs that enhance cannabinoid type-1 (CB1) receptor action may abet anxiolytic and antidepressant effects, whilst the adverse has been appear with antagonists. Thus, the cold of the present analysis is to altercate the abeyant psychiatric side-effects of CB1 receptor antagonists, such as rimonabant, which has been afresh marketed in several countries for the analysis of smoker cessation, blubber and associated metabolic disorders.
Literature searches were performed in PubMed and SciELO databases up to February 2009. The agreement searched were 'obesity', 'rimonabant', 'cannabinoids', 'unwanted effects', 'diabetes', 'smoking cessation' and 'side-effects'.
Clinical trials accept appear that rimonabant may advance weight accident in adipose patients, although it may aswell abet affection of all-overs and depression.