Drospirenone: pharmacology and pharmacokinetics of a different progestogen
The pharmacology and pharmacokinetics of drospirenone, a different progestogen, are advised in this paper. Unlike added progestogens, drospirenone, an alternation of spironolactone, has biochemical and pharmacologic profiles agnate to autogenous progesterone, abnormally apropos antimineralocorticoid and antiandrogenic activities.
Drospirenone counteracts the estrogen-induced dispatch of the renin-angiotensin-aldosterone arrangement and blocks testosterone from bounden to androgen receptors. Because of these characteristics, it has the abeyant to abate physique weight, claret pressure, and low-density lipoprotein levels and to enhance high-density lipoprotein levels. As a aggregate articulate contraceptive, drospirenone with ethinyl estradiol is able and has absolute furnishings on weight and lipid levels.
Additionally, it relieves menstrually accompanying affection (e.g., abrogating affect and baptize retention) that are frequently empiric with added aggregate articulate contraceptives. Based on the biochemical and pharmacodynamic data, drospirenone appears to be a applicable another to the currently accessible progestogens.